Injection site pain (mainly transient pain after the administration) and swelling (<5%), edema, redness, hot feeling and heaviness in the injected site (<0.1%), hypersensitivity eg, rash and itching (<0.1%), or edema (face, eyelid, etc), facial redness, nausea, vomiting, and fever may occur. Shock symptom may occur, therefore, patients should be carefully monitored and if any abnormality is observed, the administration should be discontinued and appropriate measures should be taken.